Food Grade Vitamin B3 - Essential Niacin for Health Supplement Formulations
Introduction to Niacin Technology
Vitamin B3 (Niacin) represents a critical component of human metabolism, existing in two primary forms - nicotinic acid and nicotinamide. Our food-grade niacin meets stringent international standards, offering manufacturers a versatile nutrient powder with exceptional stability and bioavailability. This high-purity ingredient serves as the precursor for NAD/NADP coenzymes involved in over 400 biochemical reactions, making it indispensable for addressing pellagra prevention, cardiovascular health, and energy metabolism support in modern nutritional formulations.
Key Product Specifications
Available Forms: Nicotinic Acid & Nicotinamide
Purity: ≥99.5% (USP/FCC/EP standards)
Appearance: White crystalline powder
Solubility:
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Nicotinic acid: 1.6g/100mL (water)
Nicotinamide: 100g/100mL (water)
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Thermal Stability: Stable up to 150°C (302°F)
Certifications: FCC, USP, EP, FDA 21CFR184.1530 GRAS
Biochemical Functions & Clinical Benefits
1. Energy Metabolism
Essential for glycolysis and Krebs cycle
NAD-dependent dehydrogenase reactions
Supports mitochondrial ATP production
2. Cardiovascular Support
Nicotinic acid modulates lipid profiles:
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Reduces LDL (10-20%)
Increases HDL (15-35%)
Lowers triglycerides (20-50%)
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3. Cellular Repair & Maintenance
PARP-mediated DNA repair
Sirtuin activation for cellular longevity
Keratinocyte differentiation support
4. Specialized Applications
Pellagra prevention/treatment
Type 1 diabetes support
Neuroprotective effects
Skin barrier enhancement
Target Populations for Supplementation
Cardiovascular Patients: Lipid management
Aging Population: NAD+ replenishment
Alcohol-dependent: Increased requirements
Vegetarians: Limited tryptophan conversion
Pregnancy: Fetal development needs
Supplement & Fortification Applications
1. Nutritional Supplements
B-complex formulations (20-500mg)
Cardiovascular support products
Energy metabolism blends
Anti-aging NAD+ boosters
2. Food Fortification
Enriched flour (24mg/lb)
Breakfast cereals
Sports nutrition products
Clinical nutrition formulas
3. Pharmaceutical Preparations
Extended-release niacin therapies
Pellagra treatment regimens
Topical acne formulations (nicotinamide)
Technical Advantages for Manufacturers
1. Enhanced Stability Profile
Resists oxidation and hydrolysis
Maintains potency in multivitamin blends
Withstands high-temperature processing
2. Bioavailability Optimization
Rapid gastrointestinal absorption
Efficient conversion to NAD/NADP
Tissue-specific utilization
3. Formulation Flexibility
Direct compression compatible
Soluble forms for liquid products
Microencapsulation options available
Quality & Safety Assurance
Global Regulatory Status
FDA: GRAS (21CFR184.1530)
EU: Approved food additive (E375)
Codex: Included in NRVs
JECFA: ADI not specified (nicotinamide)
Safety Considerations
Flushing response (nicotinic acid)
Upper limit: 35mg/day nicotinic acid
Hepatotoxicity monitoring at therapeutic doses
Quality Control Protocol
HPLC purity verification
Heavy metals
Residual solvents per ICH guidelines
Microbiological standards compliance
Usage Guidelines
Recommended Daily Intakes
Adults: 14-16mg NE
Pregnancy: 18mg NE
Therapeutic doses: 50-2000mg
Formulation Best Practices
Dry Blending: Uniform distribution
Flush-free Formulations: Inositol hexanicotinate
pH Adjustment: For improved solubility
Stability Considerations
Protect from excessive moisture
Avoid strong oxidizing agents
Nicotinamide more stable in liquids
Why Choose Our Niacin?
1. Scientific Validation
Batch-specific certification
Stability studies available
Clinical efficacy data
2. Technical Support
Flushing mitigation strategies
Solubility enhancement
Regulatory documentation
3. Supply Chain Excellence
cGMP manufacturing
Multiple packaging options
Global distribution network
Market Trends & Innovations
Longevity Science: NAD+ boosting formulations
Cardiovascular Health: Non-flushing technologies
Sports Nutrition: Energy metabolism optimization
Beauty Supplements: Skin health applications
Sustainability Features
Eco-friendly synthesis
Reduced packaging waste
Energy-efficient production
| PSA | 55.98 |
| XLogP3 | 0.8808 |
| Appearance | Nicotinamide is a white powder. (NTP, 1992) |
| Density | 1.400 g/cm3 @ Temp: 25 °C |
| Melting Point | 130 °C |
| Boiling Point | 157 ðC @ Press: 5 x 10-4àTorr |
| Flash Point | 182°C |
| Refractive Index | 1.4660 (estimate) |
| Water Solubility | 1000 g/L (20ºC) |
| Vapor Pressure | Vapour pressure, kPa at 35°C: 3.1 |
| Vapor Density | Relative vapour density (air = 1): 4.2 |
| Toxicity | LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson) |
| Odor | Odorless |
| Taste | Bitter taste |
| PH | 10% "wt in vol" solution in water is neutral to litmus |
| PKA | 3.35(at 20 °C) |
Use:
1. Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics. WWW Link
2. Niacinamide USP DC is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals WWW Link
3. A water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH.
4. Vitamin B3; enzyme cofactor; anti-pellagra
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About Beijing TDD E-commerce Co., Ltd.
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