High Purity Sodium Ascorbate USP - Vitamin C Source for Food and Supplements
Introduction
Sodium ascorbate, a buffered form of vitamin C, is a highly bioavailable and non-acidic antioxidant widely used in food fortification, dietary supplements, and pharmaceutical applications. As the sodium salt of ascorbic acid, it offers all the benefits of vitamin C without the gastric irritation associated with acidic forms, making it ideal for sensitive individuals.
Meeting United States Pharmacopeia (USP) standards, high-purity sodium ascorbate is a preferred ingredient in functional foods, effervescent tablets, immune-support supplements, and processed foods requiring oxidation protection. This article explores its properties, health benefits, applications, and regulatory compliance, providing manufacturers with a comprehensive understanding of its role in nutrition and food science.
Key Properties of USP-Grade Sodium Ascorbate
1. Superior Bioavailability
Sodium ascorbate is rapidly absorbed in the digestive tract, ensuring efficient vitamin C delivery compared to some synthetic forms.
Its neutral pH (unlike acidic ascorbic acid) minimizes stomach discomfort, making it suitable for children and individuals with acid sensitivity.
2. High Solubility & Stability
Highly water-soluble, enabling easy incorporation into beverages, injections, and liquid formulations.
More stable than pure ascorbic acid in oxygen-rich environments, extending shelf life in fortified products.
3. Antioxidant & Pro-Collagen Effects
Scavenges free radicals, protecting cells from oxidative stress.
Essential for collagen synthesis, supporting skin, joint, and vascular health.
4. Electrolyte Balance Support
Provides small amounts of sodium (~12% by weight), which can aid in electrolyte replenishment in sports nutrition products.
5. Compliance with USP Standards
Tested for purity (≥99%), heavy metals, and microbial contamination to ensure pharmaceutical-grade quality.
Health Benefits in Food & Supplement Applications
1. Immune System Support
Enhances white blood cell function and antibody production, commonly used in immune-boosting supplements.
2. Antioxidant Protection in Foods
Prevents oxidation in meat, beverages, and oils, maintaining freshness and color stability.
3. Iron Absorption Enhancement
Converts ferric iron (Fe³⁺) to absorbable ferrous iron (Fe²⁺), making it valuable in iron-fortified foods.
4. Skin Health & Anti-Aging
Stimulates collagen production, reducing wrinkles and improving skin elasticity (used in beauty supplements).
5. Cardiovascular & Cognitive Support
Reduces oxidative stress linked to heart disease and age-related cognitive decline.
Applications in Food & Supplement Industries
1. Dietary Supplements
Effervescent tablets & powders – Neutral pH prevents throat irritation.
Capsules & chewables – Preferred for children’s vitamin C products.
Multivitamin blends – Compatible with other nutrients like zinc and magnesium.
2. Functional Foods & Beverages
Fortified juices & sports drinks – Enhances nutritional profile without altering taste.
Cereal & snack bars – Protects against oxidation while adding vitamin C benefits.
3. Meat Preservation
Cured & processed meats – Works synergistically with nitrites to reduce nitrosamine formation.
4. Dairy & Plant-Based Products
Cheese & milk alternatives – Prevents vitamin degradation during storage.
5. Pharmaceutical Uses
Injectable vitamin C solutions – Used in clinical settings for high-dose therapy.
Regulatory & Safety Considerations
1. Global Approvals
FDA (21 CFR 182.3731) – GRAS-listed for food and supplements.
EU (E301) – Approved as a food additive and supplement ingredient.
Codex Alimentarius – Permitted in multiple food categories.
2. Safety Profile
No known toxicity at recommended doses (UL = 2,000 mg/day for adults).
Excess sodium intake should be monitored in hypertensive individuals.
Why Choose USP-Grade Sodium Ascorbate?
1. Purity Assurance
USP verification ensures absence of contaminants like lead or solvents.
2. Versatility
Suitable for acidic-sensitive formulations where plain ascorbic acid fails.
3. Consumer Preference
Gentler on digestion, expanding marketability to sensitive demographics.
Future Trends & Alternatives
Liposomal vitamin C – Higher absorption but costly.
Natural fruit extracts – Lower potency but appeal to clean-label demand.
Molecular Weight | 198.11 |
Exact Mass | 198.014038 |
BRN | 3767246 |
EC Number | 205-126-1 |
UNII | S033EH8359 |
DSSTox Substance ID | DTXSID0020105 |
Color/Form | Minute crystals|Minute white to yellow crystals |
PSA | 110 |
XLogP3 | -1.5349 |
Appearance | white to slightly yellow powder |
Density | 1.799 g/cm3 |
Melting Point | 220 °C |
Boiling Point | 235 °C |
Flash Point | 238.2ºC |
Refractive Index | 105.5 ° (C=10, H2O) |
Water Solubility | H2O: 620 g/L (20 ºC) |
Storage Conditions | Store at RT. |
Vapor Pressure | 1.62E-14mmHg at 25°C |
Flammability characteristics | Flammable; burning produces toxic sodium oxide fumes |
Specific rotation | 104 º (c=1, H2O 25 ºC) |
Odor | Odorless |
PH | Between 6,5 and 8,0 (10 % aqueous solution) |
Air and Water Reactions | Water soluble. Aqueous solutions are subject to quick air oxidation at pH greater than 6.0. |
Reactive Group | Alcohols and Polyols |

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